Index
Module 15 • Shock & Hemodynamics
Shock Syndromes I
91%
Core Content
Shock Syndromes I
Gretchen L. Sacha ~4 min read Module 15 of 20
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Shock Syndromes I

Kumar A, Ellis P, Arabi Y, et al. Initiation of inappropri-

ate antimicrobial therapy results in a fivefold reduction of

survival in human septic shock. Chest. 2009;136(5):1237-

1248. https://doi.org/10.1378/chest.09-0087

Kumar A, Roberts D, Wood KE, et al. Duration of

hypotension before initiation of effective antimicrobial

therapy is the critical determinant of survival in human

septic shock. Crit Care Med. 2006;34(6):1589-1596.

https://doi.org/10.1097/01.ccm.0000217961.75225.e9

Kumar A, Safdar N, Kethireddy S, Chateau D. A sur-

vival benefit of combination antibiotic therapy for serious

infections associated with sepsis and septic shock is

contingent only on the risk of death: a meta-analytic/

meta-regression study. Crit Care Med. 2010;38(8):1651-

1664. https://doi.org/10.1097/ccm.0b013e3181e96b91

Lamontagne F, Masse MH, Menard J, et al. Intravenous

vitamin C in adults with sepsis in the intensive care

unit. N Engl J Med. 2022;386(25):2387-2398. https://doi.

org/10.1056/nejmoa2200644

Landry DW, Oliver JA. The pathogenesis of vasodilatory

shock. N Engl J Med. 2001;345(8):588-595. https://doi.

org/10.1056/nejmra002709

Leisman D, Huang V, Zhou Q, et al. Delayed second

dose antibiotics for patients admitted from the emer-

gency department with sepsis: prevalence, risk factors,

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https://doi.org/10.1097/ccm.0000000000002377

Levy MM, Evans LE, Rhodes A. The Surviving

Sepsis Campaign bundle: 2018 update. Crit Care

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https://doi.org/10.1097/

ccm.0000000000003119

Marik PE. Early management of severe sepsis: concepts

and controversies. Chest. 2014;145(6):1407-1418. https://

doi.org/10.1378/chest.13-2104

Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas

J. Hydrocortisone, vitamin C, and thiamine for the treat-

ment of severe sepsis and septic shock: a retrospective

before-after study. Chest. 2017;151(6):1229-1238. https://

doi.org/10.1016/j.chest.2016.11.036

Meyhoff TS, Hjortrup PB, Wetterslev J, et al. Restriction

of intravenous fluid in ICU patients with septic shock.

N Engl J Med. 2022;386(26):2459-2470. https://doi.

org/10.1056/nejmoa2202707

Meyhoff TS, Møller MH, Hjortrup PB, Cronhjort M,

Perner A, Wetterslev J. Lower vs higher fluid volumes

during initial management of sepsis: a systematic

review with meta-analysis and trial sequential analysis.

Chest. 2020;157(6):1478-1496. https://doi.org/10.1016/j.

chest.2019.11.050

Morelli A, Ertmer C, Rehberg S, et al. Phenylephrine

versus norepinephrine for initial hemodynamic support

of patients with septic shock: a randomized, controlled

trial. Crit Care. 2008;12(6):R143. https://doi.org/10.1186/

cc7121

Moskowitz A, Huang DT, Hou PC, et al. Effect of ascor-

bic acid, corticosteroids, and thiamine on organ injury

in septic shock: the ACTS randomized clinical trial.

JAMA. 2020;324(7):642-650. https://doi.org/10.1001/

jama.2020.11946

Mouncey PR, Osborn TM, Power GS, et al. Trial of early,

goal-directed resuscitation for septic shock. N Engl J

Med. 2015;372(14):1301-1311. https://doi.org/10.1056/

nejmoa1500896

Nagendran M, Russell JA, Walley KR, et al. Vasopressin

in septic shock: an individual patient data meta-anal-

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s00134-019-05620-2

National Heart, Lung, and Blood Institute Prevention

and Early Treatment of Acute Lung Injury Clinical Trials

Network; Shapiro NI, Douglas IS, Brower RG, et al. Early

restrictive or liberal fluid management for sepsis-induced

hypotension. N Engl J Med. 2023;388(6):499-510. https://

doi.org/10.1056/nejmoa2212663

Ospina-Tascon G, Neves AP, Occhipinti G, et al. Effects

of fluids on microvascular perfusion in patients with

severe sepsis. Intensive Care Med. 2010;36(6):949-955.

https://doi.org/10.1007/s00134-010-1843-3

Perner A, Haase N, Guttormsen AB, et al. Hydroxyethyl

starch 130/0.42 versus Ringer’s acetate in severe sep-

sis. N Engl J Med. 2012;367(2):124-134. https://doi.

org/10.1056/nejmoa1204242

Polito A, Parisini E, Ricci Z, Picardo S, Annane D.

Vasopressin for treatment of vasodilatory shock: an

ESICM systematic review and meta-analysis. Intensive

Care Med. 2012;38(1):9-19. https://doi.org/10.1007/

s00134-011-2407-x

ProCESS Investigators; Yealy DM, Kellum JA, Huang

DT, et al. A randomized trial of protocol-based care for

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