Infectious Diseases II
Severe infections sometimes warrant a reduction in maintenance immunosuppression. Consult
with the transplant team regarding plans for maintenance immunosuppression.
| d. | Be aware of the many drug interactions between immunosuppressants and antimicrobials. |
|---|
Conventional
nosocomial
infections
Unconventional or opportunistic infections
Community-acquired
persistent infections
Viral
HSV
Onset of CMV
CMV retinitis or colitis
EBV, VZV, influenza, RSV, adenovirus
Papillomavirus, PTLD
Onset of hepatitis B or hepatitis C
Bacterial
Wound infections, catheter-related infections, pneumonia
Nocardia
Listeria, tuberculosis
Fungal
Pneumocystis
Aspergillus
Cryptococcus
Candida
Endemic fungi
Parasitic
Strongyloides
Toxoplasma
Leishmania
Trypanosoma cruzi
Months After Transplant
aZero indicates the time of transplantation. Solid lines indicate the most common period for the onset of infection; dotted lines indicate periods of continued risk at a
reduced level.
CMV = cytomegalovirus; EBV = Epstein-Barr virus; HSV = herpes simplex virus; PTLD = posttransplant lymphoproliferative disease; RSV = respiratory syncytial
virus; VZV = varicella-zoster virus.
Reproduced with permission from: Baillie GM. Infectious disease concerns in solid organ transplantation. In: Schumock GT, Brundage DM, Dunsworth TS, et al., eds.