Toxicology

2007;50:292-313):

Presentation more than 24 hours postingestion

ii.

An unknown or unreliable history of ingestion

iii.

Overdoses with extended-release formulations

iv.

Chronic or repeated supratherapeutic ingestions

Patients with preexisting hepatic disease, chronic alcohol use, or concurrent medications

metabolized by the CYP system or that alter gastric motility.

Reprinted from: Tylenol for Healthcare Professionals. Guidelines for the Management of Acetaminophen Overdose. McNeil Consumer & Specialty Pharmaceuticals.

Available at www.tylenolprofessional.com/guidelines-and-studies.html.