Index
Module 17 • PADIS
Pain, Agitation/Sedation, Delirium, Immobility & Sleep
87%
Core Content
Pain, Agitation/Sedation, Delirium, Immobility & Sleep
Joanna L. Stollings ~3 min read Module 17 of 20
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Pain, Agitation/Sedation, Delirium, Immobility, Sleep Disruption, and Neuromuscular Blockade

Riker

RR,

Shehabi

Y,

Bokesch

PM,

et

al.

Dexmedetomidine vs midazolam for sedation of critically

ill patients: a randomized trial. JAMA. 2009;301(5):489-

499. https://doi.org/10.1001/jama.2009.56

Seymour CW, Pandharipande PP, Koestner T, et al.

Diurnal sedative changes during intensive care: impact

on liberation from mechanical ventilation and delirium.

Crit Care Med. 2012;40(10):2788-2796. https://doi.

org/10.1097/ccm.0b013e31825b8ade

Shafer A. Complications of sedation with midazolam

in the intensive care unit and a comparison with other

sedative regimens. Crit Care Med. 1998;26(5):947-956.

https://doi.org/10.1097/00003246-199805000-00034

Shehabi Y, Bellomo R, Reade MC, et al. Early inten-

sive care sedation predicts long-term mortality in

ventilated critically ill patients. Am J Respir Crit Care

Med.

2012;186(8):724-731.

https://doi.org/10.1164/

rccm.201203-0522oc

Shehabi Y, Howe BD, Bellomo R, et al. Early sedation

with dexmedetomidine in critically ill patients. N Engl

J Med. 2019;380(26):2506-2517. https://doi.org/10.1056/

nejmoa1904710

Swart EL, de Jongh J, Zuideveld KP, Danhof M, Thijs

LG, Strack van Schijndel RJ. Population pharmacokinet-

ics of lorazepam and midazolam and their metabolites in

intensive care patients on continuous venovenous hemo-

filtration. Am J Kidney Dis. 2005;45(2):360-371. https://

doi.org/10.1053/j.ajkd.2004.09.004

Uijtendaal EV, van Harssel LL, Hugenholtz GW, et al.

Analysis of potential drug-drug interactions in medi-

cal intensive care unit patients. Pharmacotherapy.

2014;34(3):213-219. https://doi.org/10.1002/phar.1395

Verbeeck RK. Pharmacokinetics and dosage adjust-

ment in patients with hepatic dysfunction. Eur J

Clin Pharmacol. 2008;64(12):1147-1161. https://doi.

org/10.1007/s00228-008-0553-z

Vonbach P, Dubied A, KrΓ€henbΓΌhl S, Beer JH.

Prevalence of drug-drug interactions at hospital entry

and during hospital stay of patients in internal medi-

cine. Eur J Intern Med. 2008;19(6):413-420. https://doi.

org/10.1016/j.ejim.2007.12.002

Delirium

Adler J, Malone D. Early mobilization in the intensive

care unit: a systematic review. Cardiopulm Phys Ther J.

2012;23(1):5-13.

Andersen-Ranberg NC, Poulsen LM, Perner A, et

al. Haloperidol for the treatment of delirium in ICU

patients. N Engl J Med. 2022;387(26):2425-2435. https://

doi.org/10.1056/nejmoa2211868

Brummel NE, Jackson JC, Pandharipande PP, et al.

Delirium in the ICU and subsequent long-term dis-

ability among survivors of mechanical ventilation. Crit

Care Med. 2014;42(2):369-377. https://doi.org/10.1097/

ccm.0b013e3182a645bd

Brummel NE, Vasilevskis EE, Han JH, Boehm L, Pun

BT, Ely EW. Implementing delirium screening in the

ICU: secrets to success. Crit Care Med. 2013;41(9):2196-

2208. https://doi.org/10.1097/ccm.0b013e31829a6f1e

Critical Illness Brain Dysfunction, and Survivorship

Center. ABCDEFs of prevention and safety. ICU

Delirium

Devlin JW, Roberts RJ, Fong JJ, et al. Efficacy and

safety of quetiapine in critically ill patients with

delirium: a prospective, multicenter, randomized,

double-blind, placebo-controlled pilot study. Crit

Care Med. 2010;38(2):419-427. https://doi.org/10.1097/

ccm.0b013e3181b9e302

Devlin JW, Zaal IJ, Slooter AJ. Clarifying the confusion

surrounding drug-associated delirium in the ICU. Crit

Care Med. 2014;42(6):1565-1566. https://doi.org/10.1097/

ccm.0000000000000293

Girard TD, Exline MC, Carson SS, et al. Haloperidol

and ziprasidone for treatment of delirium in critical ill-

ness. N Engl J Med. 2018;379(26):2506-2516. https://doi.

org/10.1056/nejmoa1808217

Girard TD, Pandharipande PP, Carson SS, et al.

Feasibility, efficacy, and safety of antipsychotics for

intensive care unit delirium: the MIND randomized,

placebo-controlled trial. Crit Care Med. 2010;38(2):428-

437. https://doi.org/10.1097/ccm.0b013e3181c58715

Girard TD, Pandharipande PP, Ely EW. Delirium in the

intensive care unit. Crit Care. 2008;12 Suppl 3(Suppl

3):S3. https://doi.org/10.1186/cc6149

Jackson P, Khan A. Delirium in critically ill patients. Crit

Care Clin. 2015;31(3):589-603. https://doi.org/10.1016/j.

ccc.2015.03.011

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