Index
Module 8 • Clinical Pharmacology
Pharmacokinetics/Pharmacodynamics
87%
Core Content
Pharmacokinetics/Pharmacodynamics
Joseph M. Swanson ~4 min read Module 8 of 20
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Pharmacokinetics/Pharmacodynamics

Staphylococcus aureus infections: a revised consensus

guideline and review by the American Society of Health-

System Pharmacists, the Infectious Diseases Society of

America, the Pediatric Infectious Diseases Society, and

the Society of Infectious Diseases Pharmacists. Clin

Infect Dis. 2020;71(6):1361-1364. https://doi.org/10.1093/

cid/ciaa303

Rybak MJ, Le J, Lodise TP, et al. Therapeutic moni-

toring of vancomycin for serious methicillin-resistant

Staphylococcus aureus infections: a revised consensus

guideline and review by the American Society of Health-

System Pharmacists, the Infectious Diseases Society of

America, the Pediatric Infectious Diseases Society, and

the Society of Infectious Diseases Pharmacists. Am J

Health Syst Pharm. 2020;77(11):835-864. https://doi.

org/10.1093/ajhp/zxaa036

Sader HS, Mendes RE, Kimbrough JH, Kantro V,

Castanheira M. Impact of the recent Clinical and

Laboratory Standards Institute breakpoint changes on

the antimicrobial spectrum of aminoglycosides and

the activity of plazomicin against multidrug-resis-

tant and carbapenem-resistant Enterobacterales from

United States medical centers. Open Forum Infect Dis.

2023;10(2):ofad058. https://doi.org/10.1093/ofid/ofad058

St. Peter WL, Bzowyckyj AS, Anderson-Haag T, et al.

Moving forward from Cockcroft-Gault creatinine clear-

ance to race-free estimated glomerular filtration rate to

improve medication-related decision-making in adults

across healthcare settings: a consensus of the National

Kidney Foundation Workgroup for Implementation of

Race-Free eGFR-Based Medication-Related Decisions.

Am J Health Syst Pharm. 2024 Nov 18:zxae317. https://

doi.org/10.1093/ajhp/zxae317

Sawchuk RJ, Zaske DE, Cipolle RJ, Wargin WA, Strate

RG. Kinetic model for gentamicin dosing with the

use of individual patient parameters. Clin Pharmacol

Ther.

1977;21(3):362-369.

https://doi.org/10.1002/

cpt1977213362

Secchi A, Ortanderl JM, Schmidt W, et al. Effects

of

dobutamine

and

dopexamine

on

hepatic

micro- and macrocirculation during experimental

endotoxemia: an intravital microscopic study in the

rat. Crit Care Med. 2001;29(3):597-600. https://doi.

org/10.1097/00003246-200103000-00023

Shedlofsky SI, Israel BC, McClain CJ, Hill DB, Blouin

RA. Endotoxin administration to humans inhibits hepatic

cytochrome P450-mediated drug metabolism. J Clin

Invest. 1994;94(6):2209-2214. https://doi.org/10.1172/

jci117582

Shedlofsky SI, Israel BC, Tosheva R, Blouin RA.

Endotoxin

depresses

hepatic

cytochrome

P450-

mediated drug metabolism in women. Br J Clin

Pharmacol.

1997;43(6):627-632.

https://doi.

org/10.1046/j.1365-2125.1997.00603.x

Shekar K, Roberts JA, Mcdonald CI, et al. Protein-bound

drugs are prone to sequestration in the extracorporeal

membrane oxygenation circuit: results from an ex vivo

study. Crit Care. 2015;19(1):164. https://doi.org/10.1186/

s13054-015-0891-z

Silverman HJ, Penaranda R, Orens JB, Lee NH.

Impaired beta-adrenergic receptor stimulation of cyclic

adenosine monophosphate in human septic shock:

association with myocardial hyporesponsiveness to cat-

echolamines. Crit Care Med. 1993;21(1):31-39. https://

doi.org/10.1097/00003246-199301000-00010

Somogyi AA, Shanks CA, Triggs EJ. Disposition kinet-

ics of pancuronium bromide in patients with total biliary

obstruction. Br J Anaesth. 1977;49(11):1103-1108. https://

doi.org/10.1093/bja/49.11.1103

Tarling MM, Toner CC, Withington PS, Baxter MK,

Whelpton R, Goldhill DR. A model of gastric emptying

using paracetamol absorption in intensive care patients.

Intensive Care Med. 1997;23(3):256-260. https://doi.

org/10.1007/s001340050325

Tortorici MA, Kochanek PM, Poloyac SM. Effects

of hypothermia on drug disposition, metabolism, and

response: a focus of hypothermia-mediated alterations

on the cytochrome P450 enzyme system. Crit Care

Med. 2007;35(9):2196-2204. https://doi.org/10.1097/01.

ccm.0000281517.97507.6e

Tran A, Fernando SM, Gates RS, et al. Efficacy and

safety of anti-Xa-guided versus fixed dosing of low

molecular weight heparin for prevention of venous

thromboembolism in trauma patients: a systematic

review and meta-analysis. Ann Surg. 2023;277(5):734-

741. https://doi.org/10.1097/sla.0000000000005754

Tukacs M. Pharmacokinetics and extracorporeal

membrane oxygenation in adults: a literature review.

AACN Adv Crit Care. 2018;29(3):246-258. https://doi.

org/10.4037/aacnacc2018439

Udy AA, Roberts JA, Shorr AF, Boots RJ, Lipman J.

Augmented renal clearance in septic and traumatized

patients with normal plasma creatinine concentrations:

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