Index
Module 8 • Clinical Pharmacology
Pharmacokinetics/Pharmacodynamics
77%
Core Content
Pharmacokinetics/Pharmacodynamics
Joseph M. Swanson ~3 min read Module 8 of 20
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Pharmacokinetics/Pharmacodynamics

needing replacement—evidence and implications? A

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Brown CS, Liu J, Riker RR, et al. Evaluation of free

valproate concentration in critically ill patients. Crit

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Brown G, Dodek P. An evaluation of empiric vs. nomo-

gram-based dosing of heparin in an intensive care

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Chew ML, Plotka A, Alvey CW, et al. Effect of the

gastrointestinal prokinetic agent erythromycin on the

pharmacokinetics of pregabalin controlled-release in

healthy individuals: a phase I, randomized crossover

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org/10.1007/s40261-015-0281-y

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Cummins CL, Jacobsen W, Benet LZ. Unmasking the

dynamic interplay between intestinal P-glycoprotein and

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Dahn MS, Lange P, Lobdell K, Hans B, Jacobs LA,

Mitchell RA. Splanchnic and total body oxygen con-

sumption differences in septic and injured patients.

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Dailly E, Kergueris MF, Pannier M, Jolliet P, Bourin

M. Population pharmacokinetics of imipenem in burn

patients. Fundam Clin Pharmacol. 2003;17(6):645-650.

https://doi.org/10.1046/j.1472-8206.2003.00190.x

Dasta JF, Armstrong DK. Variability in aminogly-

coside pharmacokinetics in critically ill surgical

patients. Crit Care Med. 1988;16(4):327-330. https://doi.

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Pharmacokinetic and pharmacodynamic considerations

when treating patients with sepsis and septic shock.

Clin Pharmacokinet. 2002;41(14):1135-1151. https://doi.

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Desjars P, Pinaud M, Bugnon D, Tasseau F.

Norepinephrine therapy has no deleterious renal effects in

human septic shock. Crit Care Med. 1989;17(5):426-429.

https://doi.org/10.1097/00003246-198905000-00010

Dickerson RN, Hamilton LA, Connor KA, et al.

Increased hypoglycemia associated with renal failure

during continuous intravenous insulin infusion and

specialized nutritional support. Nutrition. 2011;27(7-

8):766-772. https://doi.org/10.1016/j.nut.2010.08.009

Dickerson RN, Lynch AM, Maish GO 3rd, Croce MA,

Minard G, Brown RO. Improved safety with intravenous

insulin therapy for critically ill patients with renal failure.

Nutrition. 2014;30(5):557-562. https://doi.org/10.1016/j.

nut.2013.10.010

Dickerson RN, Maish GO 3rd, Minard G, Brown RO.

Clinical relevancy of the levothyroxine-continuous enteral

nutrition interaction. Nutr Clin Pract. 2010;25(6):646-

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Di Giantomasso D, May CN, Bellomo R. Norepinephrine

and vital organ blood flow. Intensive Care Med.

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and vital organ blood flow during experimental hyperdy-

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Di Giantomasso D, Morimatsu H, May CN, Bellomo

R. Intrarenal blood flow distribution in hyperdynamic

septic shock: effect of norepinephrine. Crit Care Med.

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Droege CA, Ernst NE, Foertsch MJ, et al. Assessment of

detectable serum tobramycin concentrations in patients

receiving inhaled tobramycin for ventilator-associated

pneumonia. Respir Care. 2022;67(1):16-23. https://doi.

org/10.4187/respcare.09412

Droege ME, Rhoades AG, Droege CA, et al. Clinical

experience, characteristics, and performance of an acet-

aminophen absorption test in critically ill patients. Am

J Ther. 2023;30(2):e95-e102. https://doi.org/10.1097/

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Dulhunty JM, Roberts JA, Davis JS, et al. A multicenter

randomized trial of continuous versus intermittent

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