Pharmacokinetics/Pharmacodynamics
subcutaneously every 12 hours, and fosphenytoin 150 mg
intravenously every 8 hours.
the decreased absorption of enterally administered
drugs?
atrophy,
pantoprazole
therapy,
abdominal surgery.
therapy.
Before E.W.’s ICU admission, his albumin concen-
tration was 3.8 g/dL, but after surgery, it decreased
to 2.1 g/dL. Given this change in albumin, which
change in the total and unbound concentration of
propofol would be most likely?
total
concentration,
decreased
unbound concentration.
unbound concentration.
unbound concentration.
total
concentration,
increased
unbound concentration.
On postoperative day 3, E.W.’s SCr increased to 3
mg/dL. On postoperative day 4, his SCr is 3.2 mg/
dL. Which variable for assessing kidney function
would be most important for determining E.W.’s
dosing adjustments?
Questions 5 and 6 pertain to the following case.
S.H. is a 35-year-old man (height 70 inches, weight
85 kg) admitted to the medical ICU because of sepsis
caused by hospital-acquired pneumonia. He is empiri-
cally treated with intermittent vancomycin, piperacillin/
tazobactam, and ciprofloxacin. His laboratory values
are as follows: SCr 1 mg/dL, BUN 12 mg/dL, and WBC
18 × 103 cells/mm3.
According to S.H.’s anticipated PK changes and
guideline recommendations, which would be the
most appropriate intravenous loading dose of
vancomycin?
S.H. is given a diagnosis of methicillin-resistant
Staphylococcus aureus hospital-acquired pneu-
monia. On day 10 of vancomycin therapy, his
vancomycin area under the curve (AUC) is 700 mg
x h/L. His previous vancomycin AUC was 425 mg x
h/L on the same dosing regimen. Which most likely
explains what transpired?
B.B. is 40-year-old woman with a surgical site
infection caused by Pseudomonas aeruginosa.
She is initiated on a piperacillin/tazobactam 3.375
g intravenous infusion over 4 hours every 8 hours.
Which is the most likely benefit of this approach
with piperacillin/tazobactam?
controlled studies.
tive controlled studies.
reviews.
spective reviews.
C.W. is a 52-year-old man admitted to the ICU for
acute respiratory failure. He is given scheduled
oral morphine for pain control. Which PK variable
would most likely affect the hepatic metabolism of
morphine?