Supportive and Preventive Medicine
org/10.1097/00003246-199912000-00034
Cook DJ, Fuller HD, Guyatt GH, et al. Risk fac-
tors for gastrointestinal bleeding in critically ill
patients. Canadian Critical Care Trials Group. N Engl
J Med. 1994;330(6):377-381. https://doi.org/10.1056/
nejm199402103300601
El-Kersh K, Jalil B, McClave SA, et al. Enteral
nutrition as stress ulcer prophylaxis in critically ill
patients: a randomized controlled exploratory study.
jcrc.2017.08.036
Guillamondegui OD, Gunter OL, Bonadies JA, et al.
Practice management guidelines for stress ulcer pro-
phylaxis 2008. Eastern Association for the Surgery of
Trauma. www.east.org
Huang HB, Jiang W, Wang CY, Qin HY, Du B. Stress
ulcer prophylaxis in intensive care unit patients receiving
enteral nutrition: a systematic review and meta-anal-
s13054-017-1937-1
Krag M, Marker S, Perner A, et al. Pantoprazole in
patients at risk for gastrointestinal bleeding in the ICU.
N Engl J Med. 2018;379(23):2199-2208. https://doi.
org/10.1056/nejmoa1714919
Krag M, Perner A, Wetterslev J, et al. Prevalence and
outcome of gastrointestinal bleeding and use of acid
suppressants in acutely ill adult intensive care patients.
org/10.1007/s00134-015-3725-1
Lin PC, Chang CH, Hsu PI, Tseng PL, Huang YB. The
efficacy and safety of proton pump inhibitors vs hista-
mine-2 receptor antagonists for stress ulcer bleeding
prophylaxis among critical care patients: a meta-anal-
org/10.1097/ccm.0b013e3181d69ccf
MacLaren R, Campbell J. Cost-effectiveness of hista-
mine receptor-2 antagonist versus proton pump inhibitor
for stress ulcer prophylaxis in critically ill patients*. Crit
ccm.0000000000000032
MacLaren R, Dionne JC, Granholm A, et al. Society
Health-System Pharmacists guideline for the prevention
of stress-related gastrointestinal bleeding in critically ill
org/10.1097/ccm.0000000000006330
MacLaren R, Reynolds PM, Allen RR. Histamine-2
receptor antagonists vs proton pump inhibitors on
gastrointestinal tract hemorrhage and infectious com-
Med.
2014;174(4):564-574.
https://doi.org/10.1001/
jamainternmed.2013.14673
Madsen KR, Lorentzen K, Clausen N, et al. Guideline
for stress ulcer prophylaxis in the intensive care unit.
Dan Med J. 2014;61(3):C4811.
Marik PE, Vasu T, Hirani A, Pachinburavan M.
Stress ulcer prophylaxis in the new millennium:
Med. 2010;38(11):2222-2228. https://doi.org/10.1097/
ccm.0b013e3181f17adf
McRorie JW, Kirby JA, Miner PB. Histamine2-receptor
antagonists: rapid development of tachyphylaxis with
repeat dosing. World J Gastrointest Pharmacol Ther.
2014;5(2):57-62. https://doi.org/10.4292/wjgpt.v5.i2.57
PEPTIC Investigators for the Australian and New
Alberta Health Services Critical Care Strategic Clinical
Network, and the Irish Critical Care Trials Group.
Effect of stress ulcer prophylaxis with proton pump
inhibitors vs histamine-2 receptor blockers on in-hos-
pital mortality among ICU patients receiving invasive
mechanical ventilation: the PEPTIC randomized
org/10.1001/jama.2019.22190
Rhodes A, Evans LE, Alhazzani W, et al. Surviving
Sepsis Campaign: international guidelines for man-
Med.
2017;45(3):486-552.
https://doi.org/10.1097/
ccm.0000000000002255
Selvanderan SP, Summers MJ, Finnis ME, et al.
Pantoprazole or placebo for stress ulcer prophylaxis
(POP-UP): randomized double-blind exploratory study.
org/10.1097/ccm.0000000000001819
Simons RK, Hoyt DB, Winchell RJ, Holbrook T,
Eastman AB. A risk analysis of stress ulceration after
trauma. J Trauma. 1995;39(2):289-294. https://doi.
org/10.1097/00005373-199508000-00017
Ye Z, Reintam Blaser A, Lytvyn L, et al. Gastrointestinal
bleeding prophylaxis for critically ill patients: a clinical